Comprehensive mapping of antigen specific T cell responses in hepatitis C virus infected patients with or without spontaneous viral clearance.
Elucidating protective immunity against HCV is important for the development of a preventative vaccine.We hypothesize that spontaneous resolution of acute HCV infection offers clue to protective immune responses, and that DAA therapy affects the quality and quantity of HCV-specific T cell responses.To test these hypotheses, we performed T cell epit